Never pick it up with bare hands
Dry ice is about −109°F (−78.5°C). Brief contact can injure skin. Use insulated gloves made for very cold materials or handle it with tongs. Keep it away from children and pets.
Keep the container vented
Dry ice changes directly from a solid into carbon dioxide gas. Store it in an insulated cooler or purpose-built container that allows gas to escape. A tightly sealed container can pressurize and rupture.
Move fresh air through the vehicle
Do not transport dry ice in a closed passenger compartment. Open windows or otherwise provide outside-air ventilation, keep the trip as short as practical and remove the dry ice when you arrive.
Do not store it in a small enclosed space
Carbon dioxide can collect in closed vehicles, closets, walk-in coolers and other confined areas. If anyone develops a headache, dizziness, nausea or trouble breathing around dry ice, move to fresh air immediately and call emergency services.
Do not eat it or leave it in a drink
Never swallow dry ice. If it is used for a visual effect in a drink or punch bowl, no one should consume the drink while any solid pieces remain.
Let leftovers disappear in a safe place
Leave unused dry ice in an open or vented container in a secure, well-ventilated location. Keep people and animals away. Do not place it in a sink, toilet, drain or closed trash container.
Safety references: CDC dry ice guidance and Cornell Environmental Health and Safety.